Which of the following is NOT a side effect associated with chemotherapy?

Chemotherapy is known for a variety of side effects due to its impact on rapidly dividing cells in the body. Nausea is a well-recognized side effect, often resulting from the chemotherapy agents affecting the gastrointestinal tract and the brain's nausea centers. Hair loss is another common effect, as chemotherapy targets not only cancer cells but also other fast-growing cells, including those in hair follicles. Fatigue is frequently reported by patients undergoing chemotherapy, stemming from the overall toll the treatment takes on the body, as well as the cancer's own effects.

Skin irritation, while it can occur in some patients, is not typically classified as a direct side effect of chemotherapy itself. Unlike the other listed side effects, which have a broader consensus in literature and clinical experience, skin irritation can be more related to external factors or specific types of chemotherapy that may cause localized reactions in certain individuals. Thus, when identifying which item does not belong among the well-established side effects of chemotherapy, skin irritation is more accurately seen as an exception compared to the more widely recognized effects of nausea, hair loss, and fatigue.