Which of the following is NOT an adverse effect of vinca alkaloids?

Vinca alkaloids, such as vincristine and vinblastine, are a class of chemotherapy drugs that are commonly used to treat various types of cancer. While they do have several known adverse effects, hypersensitivity reactions are not typically associated with these agents.

Vinca alkaloids can cause peripheral neuropathy, which is a result of their neurotoxic effects, particularly with vincristine. Myelosuppression is another common side effect, especially with vinblastine, where bone marrow function is impaired leading to decreased production of blood cells. Gastroparesis, although not a primary effect of vinca alkaloids, can occur due to the overall impact of cancer treatment on digestive function.

Hypersensitivity reactions, on the other hand, tend to be less common with vinca alkaloids compared to other chemotherapy agents such as taxanes or platinum-based drugs. Therefore, identifying hypersensitivity reactions as not being a typical adverse effect of vinca alkaloids underscores an understanding of the drug's side effect profile and differentiates it from other classes of chemotherapy.