Which of the following are vinca alkaloids?

Vinca alkaloids are a class of chemotherapy agents that are specifically derived from the periwinkle plant (Catharanthus roseus). They work by inhibiting microtubule polymerization, which is essential for cell division, leading to mitotic arrest in cancer cells. The compounds vincristine and vinblastine belong to this category and are widely used in the treatment of various types of cancers, such as leukemia and lymphomas. These drugs play a crucial role in disrupting the normal process of mitosis, which is why they are effective against rapidly dividing cancer cells.

The other listed medications belong to different families of chemotherapy agents with distinct mechanisms of action. For example, paclitaxel and docetaxel are taxanes, which stabilize microtubules rather than inhibit their formation. Doxorubicin is an anthracycline that intercalates into DNA and disrupts the replication process, while cyclophosphamide is a nitrogen mustard that acts primarily as an alkylating agent. Etoposide and teniposide are topoisomerase inhibitors that interfere with DNA replication by preventing the DNA strands from unwinding. Each of these drug classes has unique properties that differentiate them from vinca alkaloids,