Which drug is most frequently compared to Cyclophosphamide due to similar side effects?

Ifosfamide is most frequently compared to Cyclophosphamide because both are alkylating agents that share similar mechanisms of action and a comparable profile of side effects. Both drugs are used in oncology for the treatment of various cancers and can lead to similar toxicities such as myelosuppression, which is a decreased production of blood cells in the bone marrow, and potential bladder toxicity, specifically hemorrhagic cystitis.

The parallels in their side effects stem from their similar chemical structures and modes of action, which involve the alkylating process that damages DNA, leading to cell death. As a result, linked side effects such as nausea, vomiting, and increased risk of infection due to lowered white blood cell counts are common among patients treated with either of these drugs.

While the other drugs mentioned have their own particular side effects and uses, they do not exhibit the same close relationship in terms of side effects and clinical application as Cyclophosphamide and Ifosfamide do. For instance, Dacarbazine and Temozolomide are also chemotherapeutic agents but are in different classes that have distinct side effect profiles. Busulfan is known for its specific toxicity to the lungs and potential for causing veno-occlusive disease in