Which agent is known for causing peripheral neuropathy that worsens in cold temperatures?

The agent identified for causing peripheral neuropathy that worsens in cold temperatures is oxaliplatin. This platinum-based chemotherapy drug is commonly used in the treatment of colorectal cancer and is known for its distinct side effect profile.

Oxaliplatin can induce sensory neuropathy, which is characterized by symptoms such as tingling, numbness, and pain, particularly in the hands and feet. These symptoms are especially exacerbated by exposure to cold temperatures. Patients may report heightened sensitivity to cold, experiencing severe discomfort when exposed to cold environments or even cold liquids.

This characteristic aspect of oxaliplatin's side effects is important for healthcare providers to consider when monitoring patients on this medication, as the discomfort caused by cold-induced neuropathy can significantly affect a patient's quality of life and may influence their treatment choices or adherence.

Other agents like cisplatin and carboplatin can also cause peripheral neuropathy but are not specifically known for this cold sensitivity. Doxorubicin, while it has its own range of side effects, including potential cardiotoxicity, is not typically associated with peripheral neuropathy as a distinct feature.