Which adverse effect is associated specifically with docetaxel?

Docetaxel, a taxane chemotherapy agent, is specifically associated with fluid retention as an adverse effect. This phenomenon results from the drug's effects on the vascular endothelium, leading to localized edema and potentially more systemic fluid-related complications. Patients receiving docetaxel may experience weight gain and peripheral edema due to this retention, which is a notable side effect distinct from those attributed to other chemotherapeutic agents.

Other adverse effects like peripheral neuropathy, myelosuppression, and constipation can occur with various chemotherapy agents but are not uniquely characteristic of docetaxel. For example, peripheral neuropathy is more commonly linked to drugs like paclitaxel or other neurotoxic agents. Myelosuppression can occur with many chemotherapeutic agents, while constipation may arise from different drugs as well. Hence, fluid retention is specifically highlighted in the context of docetaxel treatment.