What treatment is used to prevent neurotoxic metabolites in patients receiving ifosfamide?

The treatment used to prevent neurotoxic metabolites in patients receiving ifosfamide is amifostine. Amifostine is a cytoprotective agent that acts as a free radical scavenger and provides protective effects against the neurotoxicity associated with ifosfamide. Ifosfamide can lead to the formation of neurotoxic metabolites, which may result in central nervous system side effects such as confusion, hallucinations, and seizures.

By administering amifostine, healthcare providers can help mitigate these adverse effects, thereby enhancing the safety profile of ifosfamide therapy. This protective effect is particularly important in clinical settings where the benefits of ifosfamide treatment can be compromised by the risk of neurotoxicity.