What is the maximum lifetime dose of bleomycin?

The maximum lifetime dose of bleomycin is recognized as 400 units. This limit is established due to the potential risk of pulmonary toxicity, which can occur with repetitive exposure to the drug. Bleomycin primarily induces lung damage leading to interstitial pneumonitis and pulmonary fibrosis, conditions that can severely impact respiratory function. Therefore, the maximum recommended lifetime exposure is capped at this dosage to minimize the likelihood of adverse pulmonary effects while still allowing the drug's effectiveness in treating various malignancies. Understanding this dosage limit is crucial in clinical practice to ensure patient safety, particularly in those receiving combination chemotherapy where cumulative drug effects might heighten toxicity risks.