What is the maximum dosing limitation of cisplatin per dose cycle?

Cisplatin is a platinum-based chemotherapeutic agent commonly used in the treatment of various cancers. The maximum dosing limitation of cisplatin per dose cycle is essential to prevent toxicities, particularly nephrotoxicity, which can occur with higher doses. The established maximum single dose for cisplatin is generally considered to be 100 mg/m².

Dosing beyond this threshold can increase the risk of severe side effects without providing additional therapeutic benefit. Clinical guidelines and protocols typically recommend this level to maintain efficacy while minimizing the side effects associated with high doses of cisplatin. This practice acknowledges the need for balancing effective cancer treatment with the safety and quality of life of the patient.