What is one major effect of neurotoxic metabolites from ifosfamide?

Neurotoxic metabolites from ifosfamide can lead to encephalopathy, which is a dysfunction of the brain that can manifest as confusion, drowsiness, and changes in mental status. The mechanism behind this involves the accumulation of metabolites such as chloroacetaldehyde, leading to alterations in neurotransmitter function and potentially damaging brain tissue. This neurotoxicity is a significant concern, particularly because it can manifest acutely, impacting patient care significantly.

Encephalopathy resulting from ifosfamide necessitates prompt recognition and management, distinguishing it from other potential drug-related effects that might not affect the brain directly. Understanding this relationship between ifosfamide and neurological impact is crucial for clinicians in both monitoring and mitigating side effects in affected patients.