What does "HER2-positive" mean in the context of breast cancer?

In the context of breast cancer, "HER2-positive" indicates that the cancer cells have higher levels of the HER2 protein, which is a growth factor receptor. This overexpression of HER2 can lead to more aggressive tumor growth and is associated with a particular subtype of breast cancer. Identifying HER2-positive tumors is crucial because they can benefit from targeted therapies, such as trastuzumab (Herceptin), which specifically target the HER2 protein and can improve treatment outcomes for patients.

This differentiation is vital for guiding treatment strategies, as therapies targeting HER2 can significantly affect prognosis and survival rates in patients with HER2-positive breast cancer. Understanding this distinction allows healthcare professionals to tailor their treatment plans effectively and provide patients with the best possible options based on the biological characteristics of their tumors.