What are some common AEs of cisplatin?

Cisplatin is a platinum-based chemotherapy agent frequently used in the treatment of various cancers. Among its common adverse effects, peripheral neuropathy and ototoxicity are significant concerns.

Peripheral neuropathy results from cisplatin's neurotoxic effects, which can damage the sensory nerves, leading to symptoms such as tingling, burning sensation, and loss of sensation in the extremities. This is due to the drug's ability to induce axonal degeneration and disrupt normal nerve function.

Ototoxicity involves damage to the inner ear structures, which can lead to hearing loss or balance issues. Cisplatin is well-known for its potential to cause hearing impairment, particularly when given in high doses or in combination with other ototoxic medications. The mechanism involves the generation of free radicals and oxidative stress that affect the cochlea, leading to sensory hair cell damage.

These two adverse effects are well-documented in clinical settings and can significantly impact the quality of life for cancer patients receiving cisplatin therapy. Understanding these effects is crucial for monitoring and managing side effects in patients undergoing treatment.