Cisplatin is contraindicated in patients with which type of impairment?

Cisplatin is a chemotherapeutic agent widely used in the treatment of various cancers. One of its significant dose-limiting toxicities is renal toxicity. Patients with renal impairment may not be able to adequately clear the drug from their system, which can lead to increased toxicity and associated adverse effects. This necessitates careful consideration and often precludes the use of cisplatin in patients who have compromised renal function.

Additionally, cisplatin has ototoxic potential, meaning it can adversely affect hearing. In patients with existing hearing impairment or those at increased risk for ototoxicity, the use of cisplatin may lead to further deterioration of their auditory function. This dual concern regarding both renal and auditory impairment makes cisplatin contraindicated for individuals with these conditions.

The other options do not present the same level of concern for cisplatin's specific toxicities. While cardiac and hepatic issues can complicate treatment with various medications, they are not the primary contraindications for cisplatin. Similarly, while nervous and gastrointestinal impairments can pose challenges, they are not the primary issues associated with the use of this chemotherapy agent.